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This is a retrospective case-based study conducted through the Gruppo Italiano Malattie EMatologiche dell'Adulto group looking at the clinical utility and benefit of using thrombopoietin receptor agents (TPO-RAs) as a ‘bridge’ before undergoing a splenectomy. The aim of the present study is also to verify on an Italian national scale the frequency of TPO-RA use and its impact and the safety of using these drugs in adults over the age of 18 years.